Poster session

 

It is our pleasure to announce once again that the poster awards have been awarded to following young investigators:

  • Greame M. Birdsey (P.1.10) - The transcription factor Erg regulates expression of HDAC6 and multiple pathways involved in endothelial cell migration and angiogenesis
  • Voahanginirina Randriamboavonjy (P.6.9) - Identification of septin-5 as a novel calpain substrate and its role in platelet secretion
  • Krzysztof Szade (P.12.9) - A novel spheroid-plug model to study tumor angiogenesis and development
  • Sweena M. Chaudhari (P.13.3) - Role of HIF1α in immune regulation of atherosclerosis
  • Mei Mei Wong (P.13.16) - Macrophages are critical determinants of vascular progenitor cell lineage differentiation through TNF-α mediated canonical NF-κB activation

 

We would like to congratulate to all awarded and wish them much success on continuing their science work.
Congratulations!

 

Poster list
(the order in session is alphabetical according to presenting author)

 

Session 1
Mechanisms of vasculogenesis and angiogenesis

 

P.1.1
Investigation of the regulatory role of heme oxygenase-1 and its products in VEGF-mediated angiogenesis

Andrea Bauer, Catherine C. Thornton, Hayley Mylroie, Graeme M. Birdsey, Dorian O. Haskard, Anna M. Randi and Justin C. Mason

National Heart and Lung Institute, Cardiovascular Sciences, Imperial College London, London, UK

P.1.2
Role of osteoprotegerin (OPG) in angiogenesis

Benslimane-Ahmim Zahia, Heymann Dominique, Lokajczyk Anna, Brion Régis, Dizier Blandine, Galy-Fauroux Isabelle, Colliec-Jouault Sylvia, Fischer Anne Marie, Boisson-Vidal Catherine

1-INSERM U765, Paris. 2-INSERM UMR-S 957, Nantes. 3 - IFREMER, Nantes. 4-HEGP, Paris, France

P.1.3
Circulating human progenitor cells – the sentinels of vascular repair?

Sarah L. Brice1,2, Emma Thompson1,2,3, Michaelia P. Cockshell1,2, Shaundeep Sen1,2,3 and Claudine S. Bonder1,2,3

1Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide 2Co-operative Research Centre for Biomarker Translation, LaTrobe University, Melbourne 3School of Medicine, University of Adelaide, Adelaide, Australia

P.1.4
Artificial small arteries substitute created from novel biomaterial

B. Grobelski1, D.A. Walczak2 , D. Pawelczak2, M. Kolodziejczyk3, S. Bielecki3, K. Taran4, Z. Pasieka2

1Department of Haemostasis and Haemostatic Disorders Medical University of Lodz, Poland2Department of Experimental Surgery, Medical University of Lodz, Poland3Institute of Technical Biochemistry, Technical University of Lodz, Poland 4Department of Pathology Medical University of Lodz, Poland

P.1.5
Recruitment of ECFCs at the site of a laser-induced injury is independent of platelets aggregation and fibrin generation

Lucas Hubert, Laurence Panicot-Dubois, Karim Fallague, Florence Sabatier, Françoise Dignat-George, Christophe Dubois

Inserm UMR_S608, Université de la méditerranée – Aix-Marseille II, Marseille, France

P.1.6
Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors

Kai Schledzewski1, Cyrill Géraud1, Bernd Arnold2, Shijun Wang3, Hermann-Josef Gröne3, Tibor Kempf4, Kai C. Wollert4, Beate K. Straub5, Peter Schirmacher5, Alexandra Demory1, Hiltrud Schönhaber1, Alexei Gratchev1, Lisa Dietz1, Hermann-Josef Thierse1, Julia Kzhyshkowska1 and Sergij Goerdt1

1Department of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, University of Heidelberg, and Center of Excellence in Dermatology, Mannheim, Germany. 2Department of Molecular Immunology and 3Department of Cellular and Molecular Pathology, German Cancer Research Center DKFZ, Heidelberg, Germany. 4Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany. 5Department of Pathology, University Clinic Heidelberg, University of Heidelberg, Heidelberg, Germany

P.1.7
The angiogenic factor secretoneurin activates VEGFR2 in coronary endothelial cells by operating as endogenous stimulator of VEGF binding to heparansulfate proteoglycans

Rudolf Kirchmair, Wilfried Schgoer, Karin Albrecht, Markus Theurl

Dept. of Internal Medicine 1, Medical University Innsbruck, Austria

P.1.8
PPAR-gamma heterozygosity does not impair EPC mobilization

Jerzy Kotlinowski1, Anna Grochot-Przeczek1, Magdalena Kozakowska1, Bartosz Pilecki1, Ewa Zuba-Surma1, Rafal Derlacz2,3 Attila Pap4, Laszlo Nagy4, Jozef Dulak1, Alicja Jozkowicz1

1Jagiellonian University, Department of Medical Biotechnology, Krakow, Poland; 2Adamed Ltd, R&D Department, Pienkow, Poland; 3University of Warsaw, Department of Metabolic Regulation, Warsaw, Poland; 4University of Debrecen, Department of Biochemistry and Molecular Biology, Debrecen, Hungary

P.1.9
Vascularization and blood vessel patterning of the liver in zebrafish

Nils Ohnesorge, Arndt F. Siekmann

Max Planck Institute for Molecular Biomedicine, Muenster, Germany

P.1.10
The transcription factor Erg regulates expression of HDAC6 and multiple pathways involved in endothelial cell migration and angiogenesis

Graeme M. Birdsey1, Nicky H. Dryden1, Aarti V. Shah1, Rebecca Hannah2, Maddy Parsons3, Justin C. Mason1, Marketa Zvelebil4, Bertie Gottgens2, Anne J Ridley3, Anna M. Randi1

1Cardiovascular Sciences, National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, United Kingdom; 2University of Cambridge Department of Haematology, Cambridge Institute for Medical Research, Cambridge, UK; 3Randall Division of Cell and Molecular Biophysics, King's College London, London, UK. 4Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK

P.1.11

Impaired angiogenesis: a prediction for digital ulcers in Raynaud Phenomenon

Ivone Silva, Tiago Loureiro,,José Olivira, Maria E Matos, Carlos Vasconcelos, R. Almeida

Serviço de Angiologia e Cirurgia Vascular- HSA-CHP Largo Prof Abel Salazar, Porto, Portugal

 

Session 3
Smooth muscle cells and cell death

 

P.3.1
The protease MT4-MMP is essential for maintenance of vascular smooth muscle cell phenotype and vessel homeostasis in vivo

Mara M. Alonso1, Motoharu Seiki2, Alicia G. Arroyo1

1Centro Nacional de Investigaciones Cardiovasculares Carlos III CNIC, Madrid, Spain and 2Institute of Medical Science, University of Tokyo, Tokyo, Japan

P.3.2
Adenosine A2B receptor agonism inhibits vascular smooth muscle cell proliferation and intimal hyperplasia in ApoE deficient mice

Ilze Bot1, Henk de Vries2, Martine Bot1, Theo J.C. Van Berkel1, Adriaan P. IJzerman2, Johan Kuiper1

1Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands

2Division of Medicinal Chemistry, Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands

P.3.3
PAR-2 depletion protects against the development of pulmonary hypertension

Malgorzata Wygrecka5, Philipp Markart1, Leigh M. Marsh2, BholaK. Dahal1, Ralph T. Schermuly1, Christian Taube3, Andreas Meinhardt4, Ardeschir Ghofrani1, Martin Steinhoff6, Werner Seeger1, Klaus T. Preissner5, Norbert Weissmann1, Grazyna Kwapiszewska1

1Department of Internal Medicine, 4Anatomy and 5Biochemistry, University of Giessen, Lung Centre, Giessen, Germany; 2Department of Clinical Chemistry, Philipps University, Marburg, Germany; 3III Medical Clinic, Johannes Gutenberg-University, Mainz, Germany; 6Department of Dermatology and Surgery, University of California, UCSF, San Francisco, CA, USA

 

Session 4
Reactive oxygen species and vascular dysfunction

 

P.4.1
Dual effect of homocysteine on rat neutrophils

Ekaterina A. Bryushkova, Olga V. Tyulina

M.V. Lomonosov Moscow State University, Moscow, Russia

P.4.2
Restoration of endothelial nitric oxide bioavailability in myocardial endothelial cells treated with dexamethasone

Malgorzata Burek, Kinga G. Blecharz, Johann Bauersachs, Thomas Thum, Dimitrios Tsikas, Julian Widder, N. Roewer, Carola Y. Förster

University Wuerzburg, Department of Anaesthesia and Critical Care, Wuerzburg, Germany

P.4.3
Mechanisms of cerebral arteriolar dysfunction in a mice model of chronic renal failure

Charlene Da Silveira, Sabrina Poirot, Serena Colangeli, Ziad Massy And Jean-Marc Chillon

INSERM ERI12 Faculty of Medicine and Pharmacy, Amiens, France

P.4.4
Nitroglycerin-induced endothelial dysfunction and tolerance involves adverse phosphorylation and S-glutathionylation of endothelial nitric oxide synthase – beneficial effects of therapy with the AT1-receptor blocker telmisartan

Maike Knorr1, Sebastian Steven1, Michael Hausding1,2, Swenja Kröller-Schuhmacher1,2, Matthias Oelze1, Tjebo Heeren1, Alexander Scholz1, Tommaso Gori1, Philip Wenzel1,2, Eberhard Schulz1, Andreas Daiber1, Thomas Münzel1

1 Medical Center of the Johannes Gutenberg University, Mainz, Germany, 2nd Medical Clinic, Department of Cardiology and 2Center of Thrombosis and Hemostasis (CTH), Germany

P.4.5
Comparison of direct and indirect antioxidant effects of linagliptin with other gliptins - evidence for antioxidant and antiinflammatory properties of linagliptin

Swenja Kröller-Schuhmacher1, Maike Knorr1, Matthias Oelze1, Alexandra Schuff1, Michael Hausding1, Richard Schell1, Stephan Sudowe2, Alexander Scholz1, Steffen Daub1, Susanne Karbach1, Sabine Kossmann1, Eberhard Schulz1, Tommaso Gori1, Philip Wenzel1, Thomas Klein3, Thomas Münzel1, and Andreas Daiber1

1 2nd Medical Clinic, Department of Cardiology and 2 Department of Dermatology, Medical Center of the Johannes Gutenberg University, Mainz, Germany; 3 Boehringer Ingelheim Pharma GmbH & Co. KG CardioMetabolic Diseases Research, Biberach, Germany

P.4.6
N1-methylnicotinamide improves endothelial dysfunction in human blood vessels. Direct evidence at a single cell level

Teresa B. Domagala1,2, Agata Szeffler3, Lawrence W. Dobrucki4, Jerzy Dropinski2, Stanislaw Polanski2, Magdalena Leszczynska-Wiloch3, Katarzyna Kotula-Horowitz2, Jacek Wojciechowski5, Leszek Wojnowski6, Andrzej Szczeklik2, Leszek Kalinowski3

1Department of Medical Biochemistry, Jagiellonian University School of Medicine, Krakow, Poland; 2Department of Medicine Jagiellonian University School of Medicine, Krakow, Poland; 3Department of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland

P.4.7
Investigation of GTP-cyclohydrolase 1 and its feedback regulatory protein in tetrahydrobiopterin bioavailability

Dania Hussein, Anna Starr, Manasi Nandi

King’s College London, UK

P.4.8
S-carbamoylation impairs the oxidant scavenging activity of cysteine: its possible impact on increased LDL modification in uraemia

Sabine M. Schreier1, Hannes Steinkellner1, Leopold Jirovetz2, Marcela Hermann3, Markus Exner4, Bernhard M.K. Gmeiner1*, Stylianos Kapiotis5 And Hilde Laggner 1

1Center of Pathobiochemistry and Genetics, Department of Medical Chemistry and Pathobiochemistry, Medical University of Vienna; 2Department of Clinical Pharmacy and Diagnostics, University of Vienna; 3Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University Vienna; 4Laboratorium Dr. Johannes Bauer, Vienna, 5The Central Laboratory, Hospital of the Divine Redeemer, Vienna, Austria

P.4.9
Statins inhibit glucose uptake by endothelial cells by disorganization of actin cytoskeleton

Anna Paradowska1, Oliwia Zegrocka-Stendel1, Joanna Drozdowska1, Barbara Zyzynska-Granica1, Maria A. Ciemerych2, Robert Jarzyna2, Maria J.Redowicz3, Elzbieta Kaczmarek4, Katarzyna Koziak1

1Medical University of Warsaw, Warsaw, Poland; 2Warsaw University, Warsaw, Poland; 3Nencki Institute of Experimental Biology, Warsaw, Poland; 4Harvard Medical School, Boston MA, USA

P.4.10
The monitoring of the viability of blood platelets labelled with calcein AM under different experimental conditions

Joanna Rywaniak, Boguslawa Luzak, Dominika Dudzinska, Magdalena Kostrzewa, Hassan Kassassir, Radoslaw Sychowski, Cezary Watala

Departament of Haemostasis and Haemostatic Disorders, Medical University of Lodz, Lodz, Poland

 

Session 6
Hypoxia and other vascular signaling

 

P.6.1
Vasocrine signaling from perivascular adipose tissue impairs insulin-mediated vasodilatation in muscle in early obesity

Rick I. Meijer, Erik H. Serné, John S. Yudkin, Caro-Lynn F. Alta, Eugene J. Barrett, Victor W. van Hinsbergh, Yvo M. Smulders, Etto C. Eringa

Departments of Internal medicine and Physiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, The Netherlands, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA

P.6.2
Glucocorticoid signalling and resistance at the blood-brain barrier in central nervous system disorders

Christoph Kleinschnitz, Kinga Blecharz, Timo Kahles, Tobias Schwarz, Peter Kraft, Kerstin Göbel, Sven G. Meuth, Malgorzata Burek, Serge Tha5, David Scheffer Thomas Thum, Guido Stoll, and Carola Förster

Department of Anesthesia and Critical Care, University Wuerzburg,,Neurologische Klinik und Poliklinik, Universität Würzburg, Weill Cornell Medical College, New York, Klinik und Poliklinik für Neurologie, Universität Münster, Klinik für Anästhesiologie, Universität Mainz, 6 Institut für molekulare und translationale Terapiestrategien, Medizinische Hochschule Hannover, Germany

P.6.3
Contribution of chronic hypoxia and circulating endothelial colony forming cells to angiogenesis

Laura Vroling1,2, Pieter Koolwijk1, Henk Broxterman2, Victor W.M. van Hinsbergh1

Departments: 1Physiology and 2Medical Oncology, Institute for Cardiovascular Research, VU University medical center, Amsterdam, The Netherlands

P.6.4
Elevation of IL-17 promotes leukocyte accumulation in human atherosclerotic lesions

Daria Ivanova,Albina Baskaeva, Andrey Zotikov, Nurshat Gayfullin, Natalia Kalinina, Alex Bobik

Faculty of Basic Medicine, M.V. Lomonosov Moscow State University; A.V. Vishnevsky Institute of Surgery of the Russian Academy of Medical Sciences, Moscow, Russia

P.6.5
Factor inhibiting HIF (FIH) affects formation and functionality of blood vessels, under conditions of de-regulated HIF

Judson, E., Santhakumar, K, van Eeden, F.

University of Sheffield, UK

P.6.6
Comparison of hypoxia-induced angiogenic responses of monocytes/macrophages

Sofia Konisti, Serafim Kiriakidis and Ewa Paleolog

Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London, UK

P.6.7
Characterization of thioglycine, a water-soluble hydrogen sulfide H2S donor

Zongmin Zhou1, Alexandros Tourtoglou1, Mariarosaria Bucci3, Charis Roussos1, Giuseppe Cirino3, Athanassios Giannis 2, Andreas Papapetropoulos4

1G.P. Livanos & M. Simou Laboratories, Department of Critical Care and Pulmonary Services, University of Athens Medical School, Evangelismos Hospital, Athens Greece 2Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples-Federico II, Naples, Italy 3Institut für Organische Chemie, Fakultät für Chemie und Mineralogie, Universität Leipzig, Germany 4Laboratory for Molecular Pharmacology, Department of Pharmacy, University of Patras, Patras, Greece

P.6.8
N-methyl-2-pyridone-5-carboxamide is 1-methylnicotinamide metabolite of low cyclooxygenase-dependent vasodilating activity

Tomasz Przygodzki1, Bartlomiej Grobelski1, Piotr Kazmierczak1,2, Cezary Watala1

1Department of Haemostasis and Haemostatic Disorders, Chair of Laboratory Diagnostics, Medical University of Lodz, University Clinical Hospital No 2, Lodz, Poland2Postgraduate School of Molecular Medicine, Warsaw, Poland

P.6.9
Identification of septin-5 as a novel calpain substrate and its role in platelet secretion

Voahanginirina Randriamboavonjy1, Johann Isaak1, Amro Elgheznawy1, Manuel Mayr2, Ingrid Fleming1

1Institute for Vascular Signalling, Centre for Molecular Medicine, Johann Wolfgang Goethe University, Frankfurt am Mai, Germany. 2King's College London, UK

P.6.10
RhoA dependent membrane protrusions maintain the endothelial barrier

Robert Szulcek, Cora Beckers, Jan van Bezu, Victor W. M. van Hinsbergh and Geerten P. van Nieuw Amerongen

Department of Physiology, Institute for Cardiovascular Research ICaR-VU, VU University Medical Center, Amsterdam, The Netherlands

P.6.11
Wnt4 is a novel promoter of VSMC proliferation and intimal thickening by the NFATc1 non-canonical and beta-catenin canonical pathways

Aikaterini Tsaousi, Georgia M Connolly and Sarah J. George

The University of Bristol, Bristol Royal Infirmary Level 7, Bristol, BS2 8HW, UK

P.6.12
Study on the involvement of soluble guanylyl cyclase and its different isoforms in carbon monoxide and carbon monoxide releasing molecule-2 induced vasodilatation

Kelly Decaluwé1, Bart Pauwels1, Sara Verpoest1, Peter Brouckaert2, Johan Van de Voorde1

1Department of Pharmacology, 2VIB Department of Molecular Biomedical Research,, Ghent University, Ghent, Belgium

P.6.13
Role of RhoB in the regulation of pulmonary endothelial and smooth muscle responses to hypoxia

Beata Wojciak-Stothard1, Wu Yixing 1, Dimitris Kardassis2 Eleftheria Vasilaki3, Minzhou Huang2,

George Prendergast2

1Department of Experimental Medicine and Pharmacology, Division of Medicine, Imperial College London, UK ; 2University of Crete Medical School, Heraklion, Greece, 3Ludwig Institute of Cancer Research, Uppsala, Sweden; 4Lankenau Institute for Medical Research, Wynnewood PA, USA

 

Session 7
Stem cells in cardiovascular diseases

 

P.7.1
Mapping transplanted endothelial progenitor cells migration after an acute liver injury: a bimodal PET-Luminometry imaging study

Milosz P. Kawa1, Veronica Fernandez-Ruiz2, Ivan Penuelas2, Jesus Prieto2, Bogusław Machaliński1

1Department of General Pathology, Pomeranian Medical University, Szczecin, Poland, 2Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain

P.7.2
Comparison of two angiogenic quantification methods in the matrigel assay

Cheen P. Khoo1, 2, Kingsley M.2 and Suzanne M. Watt1,2

1Stem Cell Research Laboratory, NHS Blood and Transplant, Oxford, OX3 9BQ, UK; 2Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, OX3 9DU, UK

P.7.3
Multidrug resistance proteins in human progenitor and mature endothelial cells of different tissue origins

Agnieszka Krawczenko1, Karolina Wojtowicz*1, Maria Paprocka1, Elzbieta Wojdat1, Claudine Kieda2, Danuta Dus1

1Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland; 2Centre de Biophysique Moléculaire, CNRS, 45071 Orléans, Cedex2, France

P.7.4
Endothelial progenitor cells in patients with hemorrhagic and ischemic stroke: pathophysiological role of Endothelin-1

Edyta Paczkowska, Milosz P. Kawa, Boguslaw Machalinski

Department of General Pathology, Pomeranian Medical University, 72 Powstancow Wlkp Street, 70-111 Szczecin, Poland

P.7.5
Analysis of circulating stem and progenitor cells in type 2 diabetes complicated by diabetic foot syndrome

Witold Nowak1, Ewa Zuba-Surma1, Przemyslaw Witek2, Teresa Koblik2, Sebastian Borys2, Katarzyna Kusinska1, Alicja Jozkowicz1, Maciej Malecki2 and Jozef Dulak1

1Department of Medical Biotechnology, Faculty Of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, 2Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland

P.7.6
First immortalized human CD133+CD34- endothelial progenitor cell lines

Maria Paprocka1,2, Agnieszka Krawczenko1, Aneta Kantor1, Danuta Dus1, Aude Carreau2, Catherine Grillon2 and Claudine Kieda2

1Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, 53-114 Wroclaw, Poland; 2Centre de Biophysique Moléculaire, CNRS, 45071 Orléans, Cedex2, France

 

Session 8
Angiogenesis in diseases

 

P.8.1
Chloride intracellular channel protein 4 in pulmonary endothelial angiogenesis

Vahitha B. Abdul-Salam, Lan Zhao, Luke Howard, Lao ka Hou, John Wharton, Martin R. Wilkins, Beata Wojciak-Stothard

Department of Experimental Medicine, Imperial College London,UK

P.8.2
Cigarette smoke induces Von Hippel Lindau tumor suppressor protein overexpression in skeletal muscles

Vladimir T Basic1, Ali Ateia Elmabsout1, Irfan Rahman2, Allan Sirjsö1 and Samy M Abdel-Halim3,4

1Department of Clinical Medicine, örebro, Sweden; 2Rochester University, New-York, USA; 3,4 Departments of Respiratory Medicine & Allergology, Uppsala University, Uppsala and Danderyd Hospital, Stockholm, Sweden

P.8.3
Effects of obstetric factors and storage temperatures on the yield of endothelial colony forming cells from umbilical cord blood

Kate E. Coldwell1, Stephanie J. Lee1, 2, 3 , Jennifer Kean1, 2, 4, Cheen P. Khoo1, Grigorios Tsaknakis 1, Jon Smythe1 and Suzanne M. Watt1,2

1Stem Cell Research Laboratory, NHS Blood and Transplant, Oxford, OX3 9BQ. United Kingdom; 2 Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, OX3 9DU. United Kingdom; 3Medical Sciences Division, University of Melbourne, Melbourne 3050. Australia; 4 Department of Plastic and Reconstructive Surgery, Stoke Mandeville Hospital, Aylesbury, HP21 8AL. United Kingdom

P.8.4
Proteolytic activity and vascular changes during revascularization of skin grafts

Alica, Ad, Knapik, Niels, N, Hegland, Martina, Mk, Althaus, Claudio,C, Contaldo, Pietro,P, Giovanoli, Maurizio, M,Calcagni, Nicole, N, Lindenblatt

Division of Plastic and Reconstructiv Surgery, Department of Surgery, University Hospital, Zürich, Switzerland

P.8.5
Forkhead transcription factor FOXC2 regulates regeneration of lymphatic vessels

Hélène Maby-El Hajjami1, Romain Legrand1, Naoyuki Miura2 and Tatiana V. Petrova1

1Division of Experimental Oncology, Multidisciplinary Oncology Center, University of Lausanne, 1066 Epalinges, Switzerland, 2Department of Biochemistry, Hamamatsu University School of Medicine, 431-3192 Hamamatsu, Japan

P.8.6
Complement system activation and endothelial dysfunction in patients with age-related macular degeneration AMD: possible relationship between AMD and atherosclerosis coincidence in the elderly population

Anna Machalinska1,2, Milosz Kawa3, Boguslaw Machalinski3

1Department of Histology and Embryology, Pomeranian Medical University, Szczecin, Poland,2Department of Ophthalmology, Pomeranian Medical University, Szczecin, Poland,3Department of General Pathology, Pomeranian Medical University, Szczecin, Poland

P.8.7
Culturing endothelial cells in constant high glucose and lipid exposure induces cellular senescence and alters in gene expression

Irina A. Meln, Pavel A. Butylin, Sergey V. Anisimov, Andrey Yu. Zaritskey

V.A.Almazov Federal Heart, Blood and Endocrinology Centre, Petersburg, Russia

P.8.8
Identification of molecules responsible for angiogenesis process in patients with critical lower limb ischemia

Michalowska Dagmara1, Baczynska Dagmara1, Skora Jan2, Barc Piotr2, Dobosz Tadeusz1

1 Molecular Techniques Unit, Department of Forensic Medicine, Wroclaw Medical University, Poland, 2 Department and Clinic of Vascular, General and Transplantation Surgery, Wroclaw Medical University, Poland

P.8.9
Influence of pain-free and traditional treadmill training on circulating endothelial progenitor cells, pro-angiogenic and pro-inflammatory cytokines in peripheral blood of intermittent claudication patients

Witold Nowak1, Piotr Mika2, Ewa Zuba-Surma1, Katarzyna Kusinska1 Roman Nowobilski3, Rafal Nizankowski3, Alicja Jozkowicz1, Jozef Dulak1 and Andrzej Szczeklik3

1Department of Medical Biotechnology, Faculty Of Biochemistry, Biophysics and Biotechnology Jagiellonian University, Krakow, Poland; 2Department of Clinical Rehabilitation, University School of Physical Education, Krakow, Poland; 3Department of Medicine, Jagiellonian University Medical College, Krakow, Poland

P.8.10
Angiostatic kinase inhibitors to sustain photodynamic angio-occlusion

Patrycja Nowak-Sliwinska1,2, Andrea Weiss2, Judy R. van Beijnum1, Hubert van den Bergh2, Arjan W. Griffioen1

1Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands; 2Medical Photonics Group, Institute of Bioengineering, Swiss Federal Institute of Technology EPFL, Lausanne, Switzerland

P.8.11
Anti-inflammatory and proangiogenic properties of new thiazolidinedione in endothelial cells

Martina Rudnicki1, Fernando S. Fuchigami1, Cristiane A. I. Saito1, Fernanda A. César1, Maria C. A. Lima2, Suely L. Galdino2, Ivan R. Pitta2, Dulcineia S. P. Abdalla1

1 Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil, 2Federal University of Pernambuco, Recife, Brazil

P.8.12
Cell adhesion molecules and chemokines in rheumatoid arthritis patients – correlation with the disease activity

Rupinski Robert, Walewska Ewa, Filipowicz-Sosnowska Anna, Gluszko Piotr

Department of Rheumatology, Prof. Eleonora Reicher Institute of Rheumatology, Warsaw, Poland

P.8.13
The role of interleukin 15 in angiogenesis

Barbara Zyzynska-Granica1, Joanna Drozdowska1, Anna Paradowska1, Elzbieta Kaczmarek2, Katarzyna Koziak1

1Medical University of Warsaw, Warsaw, Poland; 2Harvard Medical School, Boston MA, USA

 

Session 9
Cell polarity and cell migration

 

P.9.1
Chemotaxis of T cells towards per4ascular adipose tissue in angiotensin II dependent hypertension

Ryszard Nosalski1, Tomasz Mikolajczyk1, Agnieszka Sagan1, Dominik Skiba1, Ryszard Korbut2, Tomasz J. Guzik1

1Department of Internal and Agricultural Medicine, Jagiellonian University School of Medicine, Krakow, 2Department of Pharmacology, Jagiellonian University School of Medicine, Krakow, Poland

 

Session 12
Angiogenesis in diseases: focus on cancer

 

P.12.1
Antimetastatic activity of selected pyridinium salts given in a combination with antiplatelet drugs

Agnieszka Blazejczyk1, Marta Switalska1, Stefan Chlopicki2, Andrzej Marcinek3, Jerzy Gebicki3, Joanna Wietrzyk1

1Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland, 2Depratment of Experimental Pharmacology, Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland, 3Institute of Applied Radiation Chemistry, Technical University of Lodz, Lodz, Poland

P.12.2
VEGFR-3 directly interacts with PI3K to regulate lymphangiogenesis

Sanja Coso1, Yiping Zeng1, Kenneth Opeskin2,3, Elizabeth D. Williams1

Centre for Cancer Research, Monash Institute of Medical Research, Monash University; 2Department of Pathology, University of Melbourne; and 3Department of Anatomical Pathology, St Vincent’s Hospital, Victoria, Australia

P.12.3
Use of tumor-targeting endothelial precursor cells to carry specific anti-angiogenic decoy

Guillaume Collet1,2, Nathalie Lamerant-Fayel1, Krzysztof Szade2, Magdalena Tertil1,2, Jacek Stepniewski2, Alan Guichard1, Jozef Dulak2 and Claudine Kieda1

1Centre for Molecular Biophysics, CNRS UPR 4301, Orleans, France, 2Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland

P.12.4
A role for IKKα and β in adhesion molecule expression in human endothelial cells

Ka Ho Ho, Rebecca Scott, Carly Gamble, Andrew Paul and Robin Ple6n

SIPBS, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, UK

P.12.5
Significance of intratumoral lymphatic vessel density and peritumoral lymphatic vessel invasion identified by D2-40 in patients with esophageal cancer

Miroslaw Kozlowski1, Wojciech Naumnik2, Wojciech Laudanski1, Robert Milewski5, Lech Chyczewski2, Jacek Niklinski1,4

1Departments of: Thoracic Surgery, 2Lung Diseases and Tuberculosis, 3Pathology, 4Clinical Molecular Biology, 5Statistics and Medical Informatics, Medical University of Bialystok, Bialystok, Poland

P.12.6
Vascular targeting of bacteriochlorin photodynamic therapy of cancer

Martyna Krzykawska1, Janusz M. Dabrowski2, Grazyna Stochel2, Luis G. Arnaut3, Mariette M. Pereira3, Krystyna Urbanska1, Martyna Elas1

1Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland, 2Faculty of Chemistry, Jagiellonian University, Krakow, Poland 3Chemistry Department, University of Coimbra, Portugal

P.12.7
Vascular vs. cellular targeting of anti-tumor photodynamic therapy using bacteriochlorin derivative

Agnieszka Bem1, Martyna Krzykawska1, Janusz M. Dabrowski2, Grazyna Stochel2, Luis G. Arnaut3, Mariette M. Pereira3, Krystyna Urbanska1, Martyna Elas1

Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland, 2Faculty of Chemistry, Jagiellonian University Krakow, Poland, 3Chemistry Department, University of Coimbra, Portugal

P.12.8
HO-1 and miR-378 regulate tumor microenvironment and angiogenic potential of human lung cancer

Klaudia Skrzypek1,2, Magdalena Tertil1,2, Slawomir Golda1, Kazimierz Weglarczyk2, Halina Was1, Maciej Ciesla1, Agnieszka Loboda1, Alicja Jozkowicz1, Claudine Kieda2 and Jozef Dulak1

1Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland, 2Centre de Biophysique Moleculaire, CNRS, Rue Charles-Sadron, 45071 Orleans, France

P.12.9
A novel spheroid-plug model to study tumor angiogenesis and development

Krzysztof Szade1, Guillaume Collet2, Witold Nowak1, Alicja Jozkowicz1, Claudine Kieda2, Jozef Dulak1

1Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland; 2Glycobiology of cell recognition, Centre de Biophysique Moléculaire, UPR 4301 CNRS, Orléans, France

P.12.10
Proangiogenic enzymes in non-small cell lung carcinoma – an interplay between thymidine phosphorylase and heme oxygenase-1?

Magdalena Tertil1,2, Klaudia Skrzypek1,2, Kazimierz Weglarczyk2, Chantal Pichon2, Claudine Kieda2, Halina Was1, Alicja Jozkowicz1, Jozef Dulak1

1Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland ; 2Centre de Biophysique Moléculaire, CNRS, Rue Charles-Sadron, Orléans, France

P.12.11
Heme oxygenase-1 (HO-1) challenges the angiogenic switch in prostate cancer

Elba S. Vazquez, Geraldine Gueron, Mercedes Ferrando, Belen Elguero, Angeles Salles Adriana De Siervi.

Department of Biological Chemistry, School of Sciences, University of Buenos Aires, CONICET, Argentina

 

Session 13
Inflammation and immunity in the vascular system

 

P.13.1
Vascular remodeling in chronic inflammation is neutrophil-dependent

Piotr Baluk

Cardiovascular Research Institute, University of California, San Francisco, USA

P.13.2
Antiatherogenic and anti-inflammatory effects of novel thiazolidine-2,4-diones in RAW 264.7 macrophages and in low-density lipoprotein receptor –deficient mice

Fernanda A César1, Martina Rudnicki1, Cristiane AI Saito1, Suely L Galdino2, Ivan R Pitta2, Maria CA Lima2, Dulcineia SP Abdalla1

1Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo-SP; 2Center of Health Sciences, Federal University of Pernambuco, Recife-PE, Brazil

P.13.3
Role of HIF1α in immune regulation of atherosclerosis

Sweena M. Chaudhari, Martin Busch, Miriam Koch, Helga Manthey, Alma Zernecke

Rudolf Virchow Center, DFG-Research Center for Experimental Biomedicine, University of Wuerzburg, Germany

P.13.4
IL-1α-dependent sterile inflammation in atherosclerosis is cell type-dependent and driven by necrotic vascular smooth muscle cells

Yue Zheng, Melanie Humphry, Martin R. Bennett, Murray C.H. Clarke

Division of Cardiovascular Medicine, University of Cambridge, UK

P.13.5
Mast cell activation via complement factor C5a modulates vein graft remodeling and accelerated atherosclerosis

Margreet R. de Vries1,2, Anouk Wezel2,3, Abbey Schepers2, Johan Kuiper3, Ilze Bot3, Paul HA Quax 1,2

1 Eindhoven Laboratory for Experimental Vascular Medicine, 2 Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands, 3Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands

P.13.6
Extracellular nucleotides enhance procoagulatory profile of endothelial cells after TNFα stimulation

Joanna Drozdowska1, Barbara Zyzynska-Granica1, Anna Paradowska1, Robert Jarzyna2, Dorota Maciejko1, Elzbieta Kaczmarek3, Katarzyna Koziak1

1Medical University of Warsaw, Warsaw, Poland; 2University of Warsaw, Warsaw, Poland; 3Harvard Medical School, Boston, USA

P.13.7
Differential effect of MAP kinase phosphatase-2 over-expression in endothelial cell apoptosis and smooth muscle cell proliferation

Emma Torrance, Sameer Al-Harthi, Robin Plevin

University of Strathclyde, Glasgow, UK

P.13.8
Caveolin-1 plays a critical role in the differentiation of monocytes into macrophages

Yi Fu, Shirley Moore, Jaye PF Chin-Dusting

Vascular Pharmacology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia

P.13.9
Nod1 ligands induce coronary arteritis

Toshiro Hara, Hisanori Nishio, Shunsuke Kanno, Sagano Onoyama, Kazuyuki Ikeda

Departments of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Japan

P.13.10
Activated protein C acts as a novel ligand for the endothelial receptor, TIE-2, to enhance barrier integrity and prevent vascular leakage in a mouse model of sepsis

Nikita Minhas, Meilang Xue and Christopher J. Jackson

Sutton Arthritis Research Laboratory, Institute for Bone and Joint Research, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, Sydney, 2065, New South Wales, Australia


P.13.11
CCR4-active chemokines contribute to blood and tissue eosinophilia in Churg-Strauss syndrome

Bogdan Jakiela,Marek Sanak, Wojciech Szczeklik, Barbara Sokolowska, Hanna Plutecka, Lucyna Mastalerz, Jacek Musial, Andrzej Szczeklik

Jagiellonian University Medical College, Department of Medicine, Krakow, Poland

P.13.12
Myeloperoxidase modulates physiology of thrombocytes

Hana Kolářová1,2, Anna Klinke3, Michaela Pekarová1, Silvie Gajdová1,2, Stephan Baldus3, Lukas Kubala1

1Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic2Department of Animal Physiology, Faculty of Science, Masaryk University, Brno, Czech Republic 3Department of Cardiology, Hamburg University Heart Center, Germany

P.13.13
Endothelial dysfunction and vascular inflammation in atherosclerotic patients undergoing coronary artery bypass graft surgery

Dominik Ludew1, Karol Urbanski1, Tomasz Mikolajczyk1, Boguslaw Kapelak2 , Grzegorz Grudzien2, Grzegorz Filip2, Jerzy Sadowski2, Ryszard Korbut3, Tomasz J. Guzik1

1Department of Internal and Agricultural Medicine, Jagiellonian University School of Medicine, 2 The Department of Cardiovacular Surgery and Transplantation, John Paul II Hospital in Krakow 3Chair of Pharmacology, Jagiellonian University School of Medicine, Krakow, Poland

P.13.14
Double negative T cells in angiotensin II dependent hypertension

T. Mikolajczyk1, R. Nosalski1, A. Sagan1, D. Skiba1, D. Ludew1, P. Matusik1, J. Dulak3, R. Korbut2, T.J. Guzik1

1Department of Internal and Agricultural Medicine, Jagiellonian University School of Medicine, 2Department of Pharmacology, Jagiellonian University School of Medicine, 3Department of Medical Biotechnology, Jagiellonian University, Krakow, Poland

P.13.15
The associations of systemic and in loco fibrinolytic potential with aortic stenosis progression

Joanna Natorska1,2, Ewa Wypasek1,2 Jerzy Sadowski1,2, Anetta Undas1,2

1Institute of Cardiology, Jagiellonian University School of Medicine, Cracow, Poland

2John Paul II Hospital, Cracow, Poland

P.13.16
Macrophages are critical determinants of vascular progenitor cell lineage differentiation through TNF-α mediated canonical NF-κB activation.

Mei Mei Wong, Yanhua Hu, Bernhard Winkler, Zhongyi Zhang, Qingbo Xu

Cardiovascular Division, King’s College London BHF Centre, London U.K.

P.13.17
Tissue factor-dependent activation of coagulation contributes to the inflammation in a mouse model of sickle cell disease

Pichika Chantrathammachart, Nigel S. Key, Nigel Mackman and Rafal Pawlinski

Division of Hematology /Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

P.13.18
New thiazolidinediones with low adipogenic effects in mouse 3T3-L1 preadipocytes

Cristiane A. I. Saito1, Martina Rudnicki1, Fernanda A. César1, Fernando S. Fuchigami1, Renila Ferrer1, Sueli L. Galdino2, Ivan R. Pitta2, Maria C. A. Lima2, Dulcineia S. P. Abdalla1

1Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, Brazil, 2 Federal University of Pernambuco, Recife, Brazil

P.13.19
The role of CD14dim CD16+ monocytes in regulation of endothelial function in pathogenesis of coronary artery disease

Karol Urbanski, Dominik Ludew, Tomasz Mikolajczyk, Grzegorz Filip, Boguslaw Kapelak, Jerzy Sadowski, Ryszard Korbut, Tomasz J Guzik

Department of Internal and Agricultural Medicine Jagiellonian University School of Medicine, Krakow, Poland

P.13.20
Association of Genetic Variants in the NLRP3 region with expression of proximal genes and myocardial infarction

Geena P. Varghese1, Lasse Folkeresen3, Ali A. Elmabsout1, Anders Gabrielsen3, Jan-Håkan Jansson2, Karin Fransén1, Per Eriksson3, Allan Sirsjö1

1Department of Clinical Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden, 2Department of internal medicine, Skellefteå Hospital and Umeå University Hospital, Umeå, 3Atherosclerosis research unit, Karolinska Institutet, Stockholm, Sweden

P.13.21
Factor XIII a expression within aortic valves in patients with aortic stenosis

Ewa Wypasek1,2, Joanna Natorska1,2, Przemyslaw Kapusta2, Jerzy Sadowski1,2, Anetta Undas1,2

1Institute of Cardiology, Jagiellonian University School of Medicine, Cracow, Poland, 2John Paul II Hospital, Cracow, Poland

P.13.22
Escin attenuates cell migration induced with extracellular nucleotides by reducing sPLA2 activity

Oliwia Zegrocka-Stendel, Joanna Drozdowska, Malgorzata Dutkiewicz, Dorota Maciejko, Anna Paradowska, Barbara Zyzynska-Granica, Katarzyna Koziak

Medical University of Warsaw, Warsaw, Poland

P.13.23
Localization of melatonin receptors in the adventitia of the rat aorta

Michal Zeman,1, Martin Schepelmann2, Lubos Molcan1, Hana Uhrova2, Isabella Ellinger2

1Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University Bratislava, Bratislava, Slovak Republic, 2Department of Pathophysiology and Allergy Research, Medical University Vienna, Vienna, Austria

 

Session 14
Abdominal aortic aneurysm (AAA) and hemorraghe intraplaque

 

P.14.1
The chemokine CCL22/MDC is associated with increased aortic stiffness in ascending aortic dissection

Serge P. Bottari1,3, Laetitia Boggetto-Graham2 and Jean-Philippe Baguet2

Depts. of Biochemistry1 and Cardiology2 CHU and INSERM U10553, Grenoble, France

P.14.2
Progression of experimental abdominal aortic aneurysm is mitigated by statins

Karel Houdek1, Jiří Moláček1, Vladislav Třeška1, Věra Křížková2, Lada Eberlová2,3, Lukáš Nedorost2, Jiří Kobr4, Jan Baxa5, Kirsti Witter6, Zbyněk Tonar2

1Department of Vascular Surgery, 2Department of Histology and Embryology, 3Department of Anatomy, 4Department of Paediatrics, 5Department of Imaging Methods, Faculty of Medicine in Pilsen, Charles University in Prague, University Hospital in Pilsen, Czech Republic, 6Histology and Embryology, Department of Pathobiology, University of Veterinary Medicine, Vienna, Austria

P.14.3
MMP-13 (-77A>G) gene polymorphism is not a susceptibility factor of abdominal aortic aneurysm or aortoiliac occlusive disease

Aleksandra Korcz1, Oliwia Zakerska1, Katarzyna Pawlaczyk2, Marta Molinska-Glura2, Grzegorz Oszkinis2, Ryszard Slomski1, Marcin Gabriel2

1Polish Academy of Sciences, Institute of Human Genetics, Poznan, Poland, 2Poznan University of Medical Sciences, Poznan, Poland

P.14.4
Systemic MCP1/CCR2 blockade and leukocyte specific MCP1/CCR2 inhibition affect aortic aneurysm formation differently

Vivian de Waard, Goran Marinkovic, Ilze Bot, Saskia CA de Jager, Sara Talib, Kensuke Egashira, Margreet R de Vries, Paul HA Quax, Erik AL Biessen and Theo JC van Berkel

Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netheralands

P.14.5
The L-type calcium channel blocker diltiazem prevents aortic aneurysm formation by blood pressure-independent anti-inflammatory effects

Anja Mieth, Marc Revermann, Ralf P. Brandes

Institut für Kardiovaskuläre Physiologie, Goethe-Universität Frankfurt, Germany

P.14.6
A high red blood cell distribution width predicts failure of arteriovenous fistula

Krzysztof BojakowskiP1.3, Mensur Dzabic2 Ewa Kurzejamska2, Grzegorz Styczynski3, Piotr Andziak1, Zbigniew Gaciong3, Cecilia Söderberg-Nauclér2 and Piotr Religa2

1Department of General, Vascular and Oncologic Surgery, Warsaw University of Medicine, Warsaw, Poland; 2Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Sweden; 3Department of Internal Medicine and Hypertension, Warsaw University of Medicine, Warsaw, Poland

P.14.7
Sex-differences in the impact of paraoxonase 1 (PON1) functional SNPs on abdominal aortic aneurysms (AAA) risk

Ewa Strauss1, Krzysztof Waliszewski2, Ryszard Staniszewski2, Waclaw Majewski2, Andrzej L. Pawlak1

1Institute of Human Genetics Polish Academy of Sciences in Poznan, 2 Department of General and Vascular Surgery, Poznan University of Medical Sciences, Poznan, Poland

 

Session 15
Systems biology applied to cardiovascular disease

 

P.15.1
Liver sinusoidal endothelium: a microenvironment-dependent differentiation program

Cyrill Géraud,Kai Schledzewski, Alexandra Demory, Diana Klein, Miriam Kaus, Francis Peyre, Carsten Sticht, Konstantin Evdokimov, Shun Lu, Astrid Schmieder, Sergij Goerdt

Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Germany

P.15.2
Flowmotion in microcirculation among elderly patients with heart failure

Barbara Gryglewska, Magdalena Fedyk-Lukasik, Anna Skalska, Tomasz Grodzicki

Department of Internal Medicine and Gerontology, Jagielonian University, Medical College, Krakow, Poland

P.15.3
The comparison of antithrombotic properties of CORM-3 and CORM-A1 in arterial thrombosis in rats

Karol Kramkowski1, Agnieszka Leszczynska1, Andrzej Mogielnicki1, Roberto Motterlini2, Stefan Chlopicki3, Wlodzimierz BuczkoP1.

1Department of Pharmacodynamics, Medical University of Bialystok, Poland, 2 Department of Drug Discovery and Development, Italian Institute of Technology, Genova, Italy, 3 Experimental Pharmacology, Jagiellonian University Medical College, Krakow, Poland

P.15.4
A SILAC approach to MT1-MMP degradome in inflammatory angiogenesis

Agnieszka Martínez-Koziol1, Pilar Gonzalo1, Ángela Pollán1, Alba Mota1, Nuria Colomé2, David Montaner3, Joaquín Dopazo3, Joaquín Arribas2, Francesc Canals2, and Alicia G. Arroyo1

1Centro Nacional de Investigaciones Cardiovasculares CNIC, Madrid, Spain. 2Proteomics Laboratory and Medical Oncology Research Program Vall d’Hebron University Hospital Research Institute, Barcelona, Spain. 3Bioinformatics Department, Centro de Investigacion Príncipe Felipe, Valencia, Spain

P.15.5
Anti-atherosclerotic action of agmatine in apoE-knockout mice

Anna Gebska, Anna Niepsuj, Justyna Toton-Zuranska, Rafal Olszanecki, Ryszard Korbut

Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland

P.15.6
The activity and concentration of angiotensin converting enzyme ACE and ACE 2 in the plasma and platelets of rats developing stasis induced venous thrombosis

Kamil Przyborowski, Emilia Sokolowska, Karol Kramkowski, Wlodzimierz Buczko, Andrzej Mogielnicki

Department of Pharmacodynamics, Medical University in Bialystok, Poland

P.15.7
Angiotensinogen metabolism in aorta and heart of hypertensive rats

Aneta Stachowicz, Beata Bujak-Gizycka, Maciej Suski, Jozef Madej, Rafal Olszanecki, Ryszard Korbut

Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland

P.15.8
Evaluation of cardiovascular hemodynamics and tetrahydrobiopterin levels in murine models of sepsis

Anna Starr and Manasi Nandi

Institute of Pharmaceutical Sciences, School of Biomedicine, King’s College London, UK

P.15.9
Comparative lipidomics profiling of human atherosclerotic plaques

Christin Stegemann1, Ignat Drozdov1, Joseph Shalhoub2, Julia Humphries1, Athanasios Didangelos1, Alun H Davies3, Claudia Monaco2, Alberto Smith1, Qingbo Xu1, Manuel Mayr1

1King’s BHF Centre, King’s College London, UK; 2Kennedy Institute, Imperial College London, UK; 3Imperial College, Vascular Unit, London, UK

P.15.10
Influence of angiotensin-1-7 peptidemimetic AVE 0991 on liver mitoproteome in apoE-knockout mice

Maciej Suski, Rafal Olszanecki, Beata Bujak-Gizycka, Jozef Madej, Aneta Stachowicz, Ryszard Korbut

Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland

P.15.11
Mechanism of systemic cholesterol efflux in humans after infusion of reconstituted high density lipoprotein

Dmitri Sviridov1, Anh Hoang1, Brian G. Drew1, Hann Low1, Alan T. Remaley2, Paul Nestel1, Bronwyn A. Kingwell1

1Baker IDI Heart and Diabetes Institute, Melbourne, Australia and 2National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA



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